Fenekansi Kiwumulo, HenryMuwonge, HarunaIbingira, CharlesKirabira, John BaptistTamale Ssekitoleko, Robert2021-12-172021-12-172021Kiwumulo, H. F., Muwonge, H., Ibingira, C., Kirabira, J. B., & Ssekitoleko, R. T. (2021). A systematic review of modeling and simulation approaches in designing targeted treatment technologies for Leukemia Cancer in low and middle income countries. Mathematical Biosciences and Engineering, 18(6), 8149-8173. DOI: 10.3934/mbe.202140410.3934/mbe.2021404https://nru.uncst.go.ug/xmlui/handle/123456789/731Virtual experimentation is a widely used approach for predicting systems behaviour especially in situations where resources for physical experiments are very limited. For example, targeted treatment inside the human body is particularly challenging, and as such, modeling and simulation is utilised to aid planning before a specific treatment is administered. In such approaches, precise treatment, as it is the case in radiotherapy, is used to administer a maximum dose to the infected regions while minimizing the effect on normal tissue. Complicated cancers such as leukemia present even greater challenges due to their presentation in liquid form and not being localised in one area. As such, science has led to the development of targeted drug delivery, where the infected cells can be specifically targeted anywhere in the body.enModeling and simulationLMICsLeukemia treatmentTargeted drug deliveryNanomedicineMagnetic strengthArticle