Mitchell, John C.Musanje, LawrenceFerracane, Jack L.2023-05-252023-05-252011Mitchell, J. C., Musanje, L., & Ferracane, J. L. (2011). Biomimetic dentin desensitizer based on nano-structured bioactive glass. Dental Materials, 27(4), 386-393.https://doi.org/10.1016/j.dental.2010.11.0190109-5641https://nru.uncst.go.ug/handle/123456789/8797This study evaluated the ability of a novel sol–gel bioactive glass, in conjunction with appropriate carrier vehicles, to reduce dentinal fluid flow, with an eye toward reducing dentinal hypersensitivity. Experiments were conducted to measure the reduction in tubule fluid flow after treatment of cut tooth surfaces with sol–gel bioactive glass particles in several carrier vehicles. Surfaces were also examined after exposure to brushing and acidic solutions. A non-bioactive particulate glass was compared. Tubular occlusion produced by the bioactive glass was observed via SEM and a sustained reduction in hydrodynamic conductance was measured after exposure to various fluids and brushing. This new material may be used with the tested carriers to significantly and durably reduce tubule fluid flow, ultimately resulting in reduced dentinal hypersensitivity.enDental hypersensitivityHydraulic conductanceDentin desensitizerBioactive glassArticle