Masila, Veronica M.Ndakala, Albert J.Midiwo, Jacob O.Byamukama, RobertKamau, Rahab W.Kumarihamy, MallikaMuhammad, Ilias2021-12-142021-12-142020Masila, V. M., Ndakala, A. J., Midiwo, J. O., Byamukama, R., Kamau, R. W., Kumarihamy, M., & Muhammad, I. (2020). Synthesis of a pyrrolidine derivative of a carvotacetone and monoterpenes for anti-methicillin-resistant Staphylococcus aureus and anti-cryptococcal properties. Natural Product Research, 1-8.https://doi.org/10.1080/14786419.2020.1833201https://doi.org/10.1080/14786419.2020.1833201https://nru.uncst.go.ug/xmlui/handle/123456789/480Monoterpene derivatives are of great biological relevance in the pharmaceutical industry. In the present study, pyrrolidine derivative of a carvotacetone, 3-O-benzylcarvotacetone (1), and selected monoterpenes (3-hydroxy-2-isopropyl-5-methyl-p benzoquinone (3) and cis-piperitol (5)) were prepared to provide (R)-1-(4-(benzyloxy)- 5-isopropyl-2-methylcyclohexa-1,3-dien-1-yl)-pyrrolidine (2), 2-isopropyl-5-methyl-3,6-dioxocyclohexa-1,4-dien-1-yl acetate (4), cis-3-hydroxypiperitone (6) and carvacrol (7). Structure of 2 was determined based on NMR and HRMS spectral data. Compound 4 exhibited activity against fungi Cryptococcus neoformans with an IC50 value of < 0.8 mg/mL. In addition, this compound 4 had an IC50 value of 14.97 mg/mL against methicillin resistant Staphylococcus aureus bacteria. Previous to the current study, both compound 6 and 7 had been reported to have anti-microbial and anti-fungal activities.enMonoterpenes; 2-Isopropyl-5-methyl-3,6-dioxocyclohexa-1,4-dien-1-yl acetateCarvacrolCis-3- hydroxypiperitoneAnti- MRSAAnti-cryptococcalArticle