Byakika-Kibwika, PaulineLamorde, MohammedMayito, JonathanNabukeera, LillianMayanja-Kizza, HarrietKatabira, EllyHanpithakpong, WaruneeObua, CelestinoPakker, NadineLindegardh, NiklasTarning, Joelde Vries, Peter J.Merry, Concepta2022-01-122022-01-122012Byakika-Kibwika et al.: Pharmacokinetics and pharmacodynamics of intravenous artesunate during severe malaria treatment in Ugandan adults. Malaria Journal 2012 11:132. doi:10.1186/1475-2875-11-13210.1186/1475-2875-11-132https://nru.uncst.go.ug/xmlui/handle/123456789/1230Severe malaria is a medical emergency with high mortality. Prompt achievement of therapeutic concentrations of highly effective anti-malarial drugs reduces the risk of death. The aim of this study was to assess the pharmacokinetics and pharmacodynamics of intravenous artesunate in Ugandan adults with severe malaria. Methods: Fourteen adults with severe falciparum malaria requiring parenteral therapy were treated with 2.4 mg/kg intravenous artesunate. Blood samples were collected after the initial dose and plasma concentrations of artesunate and dihydroartemisinin measured by solid-phase extraction and liquid chromatography-tandem mass spectrometry. The study was approved by the Makerere University Faculty of Medicine Research and Ethics Committee (Ref2010-015) and Uganda National Council of Science and Technology (HS605) and registered with ClinicalTrials.gov (NCT01122134).enPharmacokineticsPharmacodynamicsIntravenousArtesunateSevere malariaArticle