Orem, JacksonSandin, SvenOdida, MichaelWabinga, HenryMbidde, EdwardWabwire-Mangen, FredMeijer, Chris JLMMiddeldorp, Jaap M.Weiderpass, Elisabete2023-02-282023-02-282012Orem, J., Sandin, S., Weibull, C. E., Odida, M., Wabinga, H., Mbidde, E., ... & Weiderpass, E. (2012). Agreement between diagnoses of childhood lymphoma assigned in Uganda and by an international reference laboratory. Clinical epidemiology, 4, 339.https://doi.org/10.2147%2FCLEP.S35671https://nru.uncst.go.ug/handle/123456789/8014Correct diagnosis is key to appropriate treatment of cancer in children. However, diagnostic challenges are common in low-income and middle-income countries. The objective of the present study was to assess the agreement between a clinical diagnosis of childhood non- Hodgkin lymphoma (NHL) assigned in Uganda, a pathological diagnosis assigned in Uganda, and a pathological diagnosis assigned in The Netherlands. The study included children with suspected NHL referred to the Mulago National Referral Hospital, Kampala, Uganda, between 2004 and 2008. A clinical diagnosis was assigned at the Mulago National Referral Hospital, where tissue samples were also obtained. Hematoxylin and eosin-stained slides were used for histological diagnosis in Uganda, and were re-examined in a pathology laboratory in The Netherlands, where additional pathological, virological and serological testing was also carried out. Agreement between diagnostic sites was compared using kappa statistics.enEpstein-Barr virusnon-Hodgkin lymphomaBurkitt’s lymphomacancerArticle