Mubiru, James N.Garcia-Forey, MagdalenaCavazos, NicoleHemmat, PeggahDick, Edward J.Owston, Michael A.Bauer, Cassondra A.Shade, Robert E.Rogers, Jeffrey2023-06-232023-06-232012Mubiru, J. N., Garcia‐Forey, M., Cavazos, N., Hemmat, P., Dick Jr, E. J., Owston, M. A., ... & Rogers, J. (2012). Serum prostate specific antigen changes in cynomolgus monkeys (Macaca fascicularis) on a high sugar high fat diet. The Prostate, 72(5), 469-475. DOI 10.1002/pros.2144810.1002/pros.21448https://nru.uncst.go.ug/handle/123456789/8984An inverse relationship between serum prostate specific antigen (PSA) levels and body mass index (BMI) has been reported in men but not in any animal model. METHODS. Serum PSA in a colony of cynomolgus monkeys was assayed and correlated to body weight, prostate weight, and age. In addition, 15 animals were selected and fed a high sugar high fat (HSHF) diet for 49 weeks to increase their BMI and correlate it to PSA RESULTS. Serum PSA levels were positively correlated to prostate weight (r ¼ 0.515, P ¼ 0.025) and age (r ¼ 0.548, P ¼ 0.00072) but was not significantly correlated to body weight (r ¼ 0.032, P ¼ 0.419). For the animals on the HSHF diet, body weight, lean mass, fat mass, and BMI were significantly higher at 49 weeks than at baseline (P < 0.01). PSA was not significantly correlated to body weight and insulin at both baseline and 49 weeks. PSA was negatively correlated to BMI and insulin resistance (HOMA-IR) at 49 weeks but not at baseline. In addition, we observed hepatic steatosis and increases in serum liver enzymes. CONCLUSIONS. Increases in BMI in cynomolgus monkeys as a result of consuming a HSHF diet resulted in PSA changes similar to those in humans with increased BMI. Cynomolgus monkeys are a useful model for investigating the relationship between obesity, diabetes, and PSA changes resulting from prostate gland pathology.enDiabetesInsulin resistanceBMIArticle