Swarbrick, G. M.Park, B.Lancioni, C.Nsereko, M.2022-04-292022-04-292019Lancioni C, Swarbrick GM, Park B, et al. Recognition of CD8+ T-cell epitopes to identify adults with pulmonary tuberculosis. Eur Respir J 2019; 53: 1802053 [https://doi.org/10.1183/ 13993003.02053-2018].https://doi.org/10.1183/ 13993003.02053-2018https://nru.uncst.go.ug/handle/123456789/2942Tuberculosis (TB), the disease caused by Mycobacterium tuberculosis (Mtb), remains a leading cause of morbidity and mortality. Current tools to identify Mtb-infected individuals, specifically interferon-γ release assays (IGRAs) and the tuberculin skin test (TST), cannot distinguish between asymptomatic Mtb-infected individuals (latent Mtb infection (LTBI)) and those with TB [1]. Advancement of TB diagnostics and their application in TB-endemic settings requires an assay that distinguishes between individuals with LTBI and TB. In this pilot study, we compared the ability of three CD8+ T-cell-based assays to distinguish Ugandan adults with: confirmed pulmonary TB (HIV-uninfected and HIV-infected), LTBI (HIV-uninfected only), and those who are TST-negative (HIV-uninfected only).enCD8+ T-cell epitopesAdultsPulmonary tuberculosisArticle