Wynn, AdrianeNabukalu, DoreanLutalo, TomWawer, MariaChang, Larry W.Kiene, Susan M.Serwadda, David M.Sewankambo, NelsonNalugoda, FredKigozi, GodfreyWagman, Jennifer A.2025-05-172025-05-172021Wynn A, Nabukalu D, Lutalo T, Wawer M, Chang LW, Kiene SM, et al. (2021) Alcohol use during pregnancy in Rakai, Uganda. PLoS ONE 16(8): e0256434. https://doi.org/10.1371/journal. pone.0256434https://doi.org/10.1371/journal. pone.0256434https://nru.uncst.go.ug/handle/123456789/11642Antenatal alcohol use is linked to adverse maternal and neonatal outcomes. Uganda has one of the highest rates of alcohol use in sub-Saharan Africa, but the prevalence of antenatal alcohol use has not been reported in the Rakai region. Methods We used cross-sectional data from pregnant women in the Rakai Community Cohort Study between March 2017 and September 2018. Using bivariate and multivariable analyses, we assessed associations between self-reported antenatal alcohol use and sociodemographic characteristics, intimate partner violence (IPV), and HIV status. Results Among 960 pregnant women, the median age was 26 years, 35% experienced IPV in the past 12 months, 13% were living with HIV, and 33% reported alcohol use during their current pregnancy. After adjusting for marital status, education, smoking, and HIV status; Catholic religion (AOR: 3.54; 95% CI: 1.89–6.64; compared to other), bar/restaurant work (AOR: 2.40; 95% CI: 1.17–4.92; compared to agriculture), >one sex partner in past year (AOR: 1.92; 95% CI: 1.17–3.16), a partner that drank before sex in past year (AOR: 2.01; 95% CI: 1.48–2.74), and past year IPV (AOR: 1.55; 95% CI: 1.14–2.11) were associated with antenatal alcohol use. Conclusion We found that alcohol use during pregnancy was common and associated with religion, occupation, higher numbers of past year sex partners, having a partner who drank before sex in the past 12 months, and IPV experience. More research is needed to understand the quantity, frequency, and timing of antenatal alcohol use; and potential impacts on neonates; and to identify services that are acceptable and effective among pregnant women.enArticle