Namulondo, JoyceNyangiri, Oscar AsanyaKimuda, Magambo PhillipNambala, PeterNassuuna, JacentKabagenyi, JoyceEgesa, MosesNerima, BarbaraBiryomumaisho, SavinoMugasa, Claire MackAlison, ElliottHarry, NoyesTweyongyere, RobertMatovu, EnockMulindwa, Julius2025-03-092025-03-092024Namulondo, J., Nyangiri, O. A., Kimuda, M. P., Nambala, P., Nassuuna, J., Kabagenyi, J., ... & Mulindwa, J. (2024). Schistosoma mansoni coinfection is associated with high Plasmodium falciparum infection intensity among 10-15 year old children living along the Albert Nile in Uganda. https://doi.org/10.21203/rs.3.rs-4318753/v1https://doi.org/10.21203/rs.3.rs-4318753/v1https://nru.uncst.go.ug/handle/123456789/10078Background: Malaria and schistosomiasis are important parasitic diseases. Coinfections of these have been reported in areas endemic to both parasites. The aim of this study was to determine the association between Schistosoma mansoni (S. mansoni) and Plasmodium falciparum (P. falciparum) infection intensities among school age children living along the Albert Nile. Methods: A cross sectional study of 210 children aged 10–15 years, was conducted in selected sites along the Albert Nile in Pakwach District in northwest Uganda. The Circulating Anodic Antigen (CAA) test and quantitative PCR (qPCR) were used to test for S. mansoni infection intensity and quantitative PCR used to test for P. falciparum infection intensity. Results: Of the 210 study particpants, 76.2% (160/210) were malaria positive whereas 91% (191/210) were S. mansoni positive. There were only 1% (3/210) infections of each of Necator americanus and Strongyloides stercolaris. Of the P. falciparum positive children 57.5% (92/160) were male; on the other hand 53.4% (102/191) of the S. mansoni positive children were male. Overall, 150 of the 210 children tested (71%) had co-infection with both P. falciparum and S. mansoni. There was a significant association (p-value = 7.306e-10, r2  = 0.17) between P. falciparum qPCR Ct-value and S. mansoni qPCR Ct-value. There was a significant association (p-value = 7.306e-10, r2  = 0.17) between P. falciparum intensity (qPCR Ct-value) and S. mansoni intensity (qPCR Ct-value) among the children test. Conclusions: By molecular detection, this study observed a high prevalence of P. falciparum among the school age children (10–15 years) living in the S. mansoni endemic hotspots along the Albert-Nile region of Pakwach district, northwestern Uganda.enArticle