Nannyonga, Betty K.Wanyenze, Rhoda K.Kaleebu, PontianoSsenkusu, John M.Lutalo, TomMakumbi, Fredrick EdwardKwizera, ArthurByakika, PaulineKirungi, WillfordBosa, Henry KyobeSsembatya, Vincent A.Mwebesa, HenryAtwine, DianaAceng, Jane RuthWoldermariam, Yonas Tegegn2022-06-142022-06-142020Nannyonga, B. K., Wanyenze, R. K., Kaleebu, P., Ssenkusu, J. M., Lutalo, T., Makumbi, F. E., ... & Woldermariam, Y. T. (2020). Estimating the Effect and Cost-Effectiveness of Facemasks in Reducing the Spread of the Severe Acute Respiratory Syndrome-Coronavirus 2 (SARS-CoV-2) in Uganda. medRxiv.https://doi.org/10.1101/2020.06.11.20128272https://nru.uncst.go.ug/handle/123456789/3961Evidence that face masks provide effective protection against respiratory infections in the community is scarce. However, face masks are widely used by health workers as part of droplet precautions when caring for patients with respiratory infections. It would therefore be reasonable to suggest that consistent widespread use of face masks in the community could prevent further spread of the Severe Acute Respiratory Syndrome-Coronavirus 2 (SARS-CoV-2). In this study we examine public face mask wearing in Uganda where a proportion wears masks to protect against acquiring, and the other to prevent from transmitting SARS-CoV-2. The objective of this study was to determine what percentage of the population would have to wear face masks to reduce susceptibility to and infectivity of SARS-COV-2 in Uganda, keeping the basic reproduction number below unity and/or flattening the curve. We used an SEIAQRD model for the analysis. Results show that implementation of facemasks has a relatively large impact on the size of the coronavirus epidemic in Uganda. We find that the critical mask adherence is 5 per 100 when 80% wear face masks. A cost-effective analysis shows that utilizing funds to provide 1 public mask to the population has a per capita compounded cost of USD 1.34. If provision of face masks is done simultaneously with supportive care, the per capita compounded cost is USD 1.965, while for the case of only treatment and no provision of face masks costs each Ugandan USD 4.0579. We conclude that since it is hard to achieve a 100% adherence to face masks, government might consider provision of face masks in conjunction with provision of care.enArticle