Vandepitte, JudithWeiss, Helen A.Bukenya, JustineNakubulwa, SusanMayanja, YuniaMatovu, GodfreyKyakuwa, NassimHughes, PeterHayes, RichardGrosskurth, Heiner2022-05-162022-05-162013Vandepitte, J., Weiss, HA, Bukenya, J., Nakubulwa, S., Mayanja, Y., Matovu, G., ... & Grosskurth, H. (2013). Alcohol use, Mycoplasma genitalium and other STIs associated with HIV incidence among women at high risk in Kampala, Uganda. Journal of acquired immune deficiency syndromes (1999) , 62 (1), 119. doi:10.1097/QAI.0b013e3182777167.10.1097/QAI.0b013e3182777167.https://nru.uncst.go.ug/handle/123456789/3238In 2008, the first clinic for women involved in high risk sexual behaviour was established in Kampala, offering targeted HIV prevention. This paper describes rates, determinants and trends of HIV incidence over 3 years. Methods—1027 women at high risk were enrolled into a closed cohort. At 3-monthly visits, data were collected on socio-demographic variables and risk behaviour; biological samples were tested for HIV and other STIs. Hazard ratios (HR) for HIV incidence were estimated using Cox proportional hazards regression, among the 646 women HIV negative at enrolment. Results—HIV incidence was 3.66/100pyr and declined from 6.80/100pyr in the first calendar year to 2.24/100pyr and 2.53/100pyr in the following years (P-trend=0.003). Socio-demographic and behavioural factors independently associated with HIV incidence were younger age, younger age at first sex, alcohol use (including frequency of use and binge drinking), number of paying clients in the past month, inconsistent condom use with clients, and not being pregnant. HIV incidence was also independently associated with M. genitalium infection at enrolment (aHR=2.28, 95%CI: 1.15-4.52), and with N. gonorrhoeae (aHR=5.91, 95%CI: 3.04-11.49) and T. vaginalis infections at the most recent visit (aHR=2.72, 95%CI: 1.27-5.84). The PAF of HIV incidence for alcohol use was 63.5% (95%CI 6.5%-85.8%), and for treatable STI/RTI was 70.0% (95%CI 18.8%-87.5%). Conclusions—Alcohol use and STIs remain important risk factors for HIV acquisition, which call for more intensive control measures in women at high risk. Further longitudinal studies are needed to confirm the association between Mycoplasma genitalium and HIV acquisition.enHIV incidenceMycoplasma genitaliumSTIsAlcoholWomen at high riskRisk factorsUgandaArticle