Nalwoga, AngelaCose, StephenWakeham, KatieMiley, WendellNdibazza, JulietDrakeley, ChristopherElliott, AlisonWhitby, DeniseNewton, Robert2022-01-302022-01-302015Nalwoga, A., Cose, S., Wakeham, K., Miley, W., Ndibazza, J., Drakeley, C., ... & Newton, R. (2015). Association between malaria exposure and Kaposi's sarcoma‐associated herpes virus seropositivity in Uganda. Tropical medicine & international health, 20(5), 665-672. doi:10.1111/tmi.1246410.1111/tmi.12464https://nru.uncst.go.ug/xmlui/handle/123456789/1631Unlike other herpes viruses, Kaposi’s sarcoma-associated herpes virus (KSHV) is not ubiquitous worldwide and is most prevalent in sub-Saharan Africa. The reasons for this are unclear. As part of a wider investigation of factors that facilitate transmission in Uganda, a high prevalence country, we examined the association between antimalaria antibodies and seropositivity against KSHV. Antibodies against P. falciparum merozoite surface protein (PfMSP)-1, P. falciparumapical membrane antigen (PfAMA)-1 and KSHV antigens (ORF73 and K8.1) were measured in samples from 1164 mothers and 1227 children. results Kaposi’s sarcoma-associated herpes virus seroprevalence was 69% among mothers and 15% children. Among mothers, KSHV seroprevalence increased with malaria antibody titres: from 60% to 82% and from 54% to 77%, comparing those with the lowest and highest titres for PfMSP- 1 and PfAMA-1, respectively (P < 0.0001). Among children, only antibodies to PfAMA-1 were significantly associated with KSHV seropositivity, (P < 0.0001). In both mothers and children, anti- ORF73 antibodies were more strongly associated with malaria antibodies than anti-K8.1 antibodies. conclusion The association between malaria exposure and KSHV seropositivity suggests that malaria is a cofactor for KSHV infection or reactivation.enKaposi’s sarcoma-associated herpes virusMalariaUgandaArticle