Jjingo, DaudiWang, JianrongConley, Andrew B.Lunyak, Victoria V.Jordan, I. King2021-12-132021-12-132013Jjingo, D., Wang, J., Conley, A. B., Lunyak, V. V., & Jordan, I. K. (2013). Compound cis-regulatory elements with both boundary and enhancer sequences in the human genome. Bioinformatics, 29(24), 3109-3112. doi:10.1093/bioinformatics/btt54210.1093/bioinformatics/btt542https://nru.uncst.go.ug/xmlui/handle/123456789/446It has been suggested that presumably distinct classes of genomic regulatory elements may actually share common sets of features and mechanisms. However, there has been no genome-wide assessment of the prevalence of this phenomenon. Results: To evaluate this possibility, we performed a bioinformatic screen for the existence of compound regulatory elements in the human genome. We identified numerous such colocated boundary and enhancer elements from human CD4þ T cells.We report evidence that such compound regulatory elements possess unique chromatin features and facilitate cell type-specific functions related to inflammation and immune response in CD4þ T cells.enCompound cis-regulatory elementsEnhancer sequencesHuman genomeArticle