Asthana, AmishKisaalita, William S.2025-04-162025-04-162016Asthana, A., & Kisaalita, W. S. (2016). Molecular basis for cytokine biomarkers of complex 3D microtissue physiology in vitro. Drug discovery today, 21(6), 950-961.http://dx.doi.org/doi:10.1016/j.drudis.2016.03.009https://nru.uncst.go.ug/handle/123456789/10810Physiologically more-relevant’claims are readily made for cells cultured on any surface or in a scaffold that provides loosely defined 3D geometry. A set of tools to measure culture ‘3D-ness’ more accurately are needed. Such tools should find applications in fields ranging from high-throughput identification of substrates for tissue engineering and regenerative medicine to cell-based screening of drug candidates. Until now, these fields have not provided a consensus for the most promising place to initiate the search. Here, we review recent advances in transcriptomic, proteomic, inflammation and oncology-related pathways, as well as functional studies that strongly point to cytokines as the most likely compounds to form the missing consensus.enArticle