Serwanga, J.Ndembi, N.Nanteza, B.Mugaba, S.Pimego, E.Pala, P.Auma, B.Lyagoba, F.Kaleebu, P.2023-03-062023-03-062009Serwanga, J., Ndembi, N., Nanteza, B., Mugaba, S., Pimego, E., Pala, P., ... & Kaleebu, P. (2009). P20-10. Differences in patterns of Gag-induced immunogenetic pressure occur between clades A and D chronic HIV-1 infection in a Ugandan population. Retrovirology, 6(3), 1-1.https://doi.org/10.1186/1742-4690-6-S3-P3801742-4690https://nru.uncst.go.ug/handle/123456789/8086We previously reported slow HIV-1 disease progression in this population to be associated with the inherent host HLA B allele-mediated ability to induce broader Gag T-cell responses and faster disease progression to be more associated with clade D than A. Since Gag escape mutations often reduce viral fitness leading to significant reduction in virus replication, in this study, we evaluated the immunogenetic characteristics of clades A and D-associated escape mutations that could be harnessed for vaccine design.enViral FitnessSubstitution A163GFast Disease ProgressionUgandan PopulationImmunogenetic CharacteristicArticle