Rhein, JoshuaTugume, LillianNuwagira, EdwinMpoza, EdwardKiggundu, ReubenSsebambulidde, KennethBoulware, David R.2025-04-032025-04-032019-08-30Rhein, J., Hullsiek, K. H., Tugume, L., Nuwagira, E., Mpoza, E., Evans, E. E., ... & Nielsen, K. (2019). Adjunctive sertraline for HIV-associated cryptococcal meningitis: a randomised, placebo-controlled, double-blind phase 3 trial. The Lancet infectious diseases, 19(8), 843-851.doi: 10.1016/S1473-3099(19)30127-6https://nru.uncst.go.ug/handle/123456789/10352Identifying new antifungals for cryptococcal meningitis is a priority given the inadequacy of current therapy. Sertraline has previously shown in vitro and in vivo activity against cryptococcus. We aimed to assess the efficacy and cost-effectiveness of adjunctive sertraline in adults with HIV-associated cryptococcal meningitis compared with placebo.enArticle