Wampande, Eddie M.Mupere, EzekielDebanne, SaraMAsiimwe, Benon B.Nsereko, MaryMayanja, HarrietEisenach, KathleenKaplan, GillaBoom, Henry W.Gagneux, SebastienJoloba, Moses L.2022-01-302022-01-302013Wampande et al.: Long-term dominance of Mycobacterium tuberculosis Uganda family in peri-urban Kampala-Uganda is not associated with cavitary disease. BMC Infectious Diseases 2013 13:484. doi:10.1186/1471-2334-13-484doi:10.1186/1471-2334-13-484https://nru.uncst.go.ug/xmlui/handle/123456789/1646Previous studies have shown that Mycobacterium tuberculosis (MTB) Uganda family, a sub-lineage of the MTB Lineage 4, is the main cause of tuberculosis (TB) in Uganda. Using a well characterized patient population, this study sought to determine whether there are clinical and patient characteristics associated with the success of the MTB Uganda family in Kampala. A total of 1,746 MTB clinical isolates collected from1992-2009 in a household contact study were genotyped. Genotyping was performed using Single Nucleotide Polymorphic (SNP) markers specific for the MTB Uganda family, other Lineage 4 strains, and Lineage 3, respectively. Out of 1,746 isolates, 1,213 were from patients with detailed clinical data. These data were used to seek associations between MTB lineage/sub-lineage and patient phenotypes.enMycobacterium tuberculosis complexLineageSingle nucleotide polymorphismMycobacteriaStrain familyCavitationVirulenceEpidemiologyEvolutionArticle