Juan, RavellOtim, IsaacNabalende, HadijahLegason, Ismail D.Reynolds, Steven J.Ogwang, Martin D.Ndugwa, Christopher M.Marshall, VickieWhitby, DeniseGoedert, James J.Engels, Eric A.Bhatia, KishorLenardo, Michael J.Mbulaiteye, Sam M.2022-04-292022-04-292018Juan, R., Otim, I., Nabalende, H., Legason, I. D., Reynolds, S. J., Ogwang, M. D., ... & Mbulaiteye, S. M. (2018). Plasma magnesium is inversely associated with Epstein-Barr virus load in peripheral blood and Burkitt lymphoma in Uganda. Cancer epidemiology, 52, 70-74. https://doi.org/10.1016/j.canep.2017.12.004https://doi.org/10.1016/j.canep.2017.12.004https://nru.uncst.go.ug/handle/123456789/2989Epstein-Barr virus (EBV) causes endemic Burkitt lymphoma (eBL). EBV control was improved by magnesium (Mg2+) supplementation in XMEN, an X-linked genetic disease associated with Mg2+ deficiency, high circulating EBV levels (viral loads), and EBV-related lymphomas. We, therefore, investigated the relationship between Mg2+ levels and EBV levels and eBL in Uganda. Methods: Plasma Mg2+ was measured in 45 women with low or high circulating EBV levels, 40 pediatric eBL cases, and 79 healthy children. Mg2+ uptake by T-lymphocytes was evaluated in samples from healthy donors. Results: Plasma Mg2+ deficiency (plasma level<1.8 mg/dl) was more likely in women with high- vs. low-EBV levels (76.0% vs. 35%; odds ratio [OR] 11.3, 95% CI 2.14–60.2), controlling for age, and in eBL cases than controls (42.0% vs. 13.9%; OR 3.61, 95% CI 1.32–9.88), controlling for sex, age group, and malaria status. Mg2+ uptake by T-lymphocytes was related to extracellular Mg2+ concentration. Interpretation: Plasma Mg2+ deficiency is associated with high EBV levels and eBL.enEpstein-Barr virusBurkitt lymphomaMagnesiumXMEN AfricaEpidemiologyArticle