Kakande, TaufikBatunge, YonahEilu, EmmanuelShabohurira, AmbroseAbimana, JustusAdekunle Akinola, SaheedMuhwezi, ReaganAdam, Abubakar S.Onkoba, Sarah K.Aliero, Adamu A.2022-12-022022-12-022019Kakande, T., Batunge, Y., Eilu, E., Shabohurira, A., Abimana, J., Akinola, S. A., ... & Ntulume, I. (2019). Prevalence of dermatophytosis and antifungal activity of ethanolic crude leaf extract of Tetradenia riparia against dermatophytes isolated from patients attending Kampala International University Teaching Hospital, Uganda. Dermatology research and practice, 2019.https://doi.org/10.1155/2019/9328621https://nru.uncst.go.ug/handle/123456789/5652Dermatophyte infections are a global health problem but neglected in Uganda. This work aimed at determining prevalence of dermatophytosis and antifungal activity of ethanolic crude leaf extract of Tetradenia riparia against dermatophytes isolated from patients attending Kampala International University Teaching Hospital (KIU-TH), Uganda. A total of 100 samples of skin and nail scrapings were collected and processed using standard microscopy (KOH) and cultural methods. T. riparia leaves were collected and processed with 95% ethanol using standard extraction method. The crude leaves ethanolic extract was tested against three dermatophytes: Trichophyton tonsurans, T. mentagrophyte, andMicrosporum audouinii using modified agar well diffusion method. Minimuminhibitory concentration (MIC) andminimumfungicidal concentration (MFC) of the ethanolic leaves crude extractwere also determined using broth tube dilution and culture, respectively. Out of 100 samples collected, 49 (49%, 95%CI: 0.3930-0.5876) were found positive for microscopy. The prevalence of dermatophytosis was significantly (p=0.001) associated with age groups of participants with higher infection among those aged 11-20 and 21-30 years with 75.0% each. Out of the 49 that were positive by microscopy, 28 (57.15%, 95% CI: 0.1987-0.3739) were positive by culture. Thirty-one (31) fungal isolates were obtained which included both dermatophyte and non-dermatophyte fungi. T. verrucosumhad highest distribution 6 (19.35%) among dermatophytes species while Aspergillus spp. were found to have highest distribution 7 (22.58%) among non-dermatophyte species.The result of the antidermatophytic test showed that T. riparia ethanolic crude leaves extract had activity against tested dermatophytes at 1 g/ml. MIC and MFC of the crude extract of T. riparia against tested dermatophytes ranged from62.5 to 250mg/ml and 125 to 500mg/ml, respectively.The findings of this study reported the presence of dermatophytes causing dermatophytosis among patients attending KIU-TH.The results of the current study showed that T. riparia leaves ethanolic crude extract has antidermatophytic activity against tested dermatophytes.enDermatophyteinfectionsKampala International UniversityUgandaArticle