Byamugisha, Josaphat K.Mirembe, Florence M.Faxelid, ElisabethTumwesigye, Nazarius M.Gemzell-Danielsson, Kristina2022-01-202022-01-202010Byamugisha, J. K., Mirembe, F. M., Faxelid, E., Tumwesigye, N. M., & Gemzell-Danielsson, K. (2010). A randomized clinical trial of two emergency contraceptive pill regimens in a Ugandan population. Acta obstetricia et gynecologica Scandinavica, 89(5), 670-676. DOI: 10.3109/0001634100361122010.3109/00016341003611220https://nru.uncst.go.ug/xmlui/handle/123456789/1375Recent trials on emergency contraception (EC) have indicated that levonorgestrel (LNG) used alone has fewer side-effects and is more efficacious than the Yuzpe regimen (high dose combined oral contraceptive pills). However, the experienced side-effects and acceptability may vary between different groups or societies. Objective. The primary objective of this study was to determine side-effects and acceptability of two emergency contraceptive pill (ECP) regimens among users in Kampala, Uganda. Study design. Randomized clinical trial. Methods. A total of 337 women were enrolled in a double blind randomized clinical trial. Women requesting ECPs within 72 hours after unprotected sexual intercourse received either LNG or the Yuzpe regimen. The women returned for follow-up after three days and a follow-up interview was performed after one year. Results. Levonorgestrel had significantly fewer side-effects than the Yuzpe regimen (p < 0.001). There was a significant association between having worries about the method and experiencing side-effects (p < 0.001). Most women (81%) were prime users of EC. The majority would recommend ECP to other clients. Conclusions. Levonorgestrel is a superior option to the Yuzpe regimen and should be promoted as the recommended ECP. Having worries about ECP may influence experience of the side-effects. Correct information is critical in promotion of ECP use.enEmergency contraceptive pillsLevonorgestrelUgandanArticle