Ocama, PonsianoKatwere, MichaelPiloya, TheresaFeld, JordanOpio, Kenneth C.Kambugu, AndrewKatabira, EllyThomas, DavidColebunders, RobertRonald, Allan2022-05-012022-05-012008Ocama, P., Katwere, M., Piloya, T., Feld, J., Opio, K. C., Kambugu, A., ... & Ronald, A. (2008). The spectrum of liver diseases in HIV infected individuals at an HIV treatment clinic in Kampala, Uganda. African health sciences, 8(1).https://www.ajol.info/index.php/ahs/article/view/6974https://nru.uncst.go.ug/handle/123456789/3103Liver diseases are common in patients with HIV due to viral hepatitis B and C co-infections, opportunistic infections or malignancies, antiretroviral drugs and drugs for opportunistic infections. Objective: To describe the spectrum of liver diseases in HIV-infected patients attending an HIV clinic in Kampala, Uganda. Method: Consecutive patients presenting with jaundice, right upper quadrant pain with fever or malaise, ascites and/or tender hepatomegaly were recruited and underwent investigations to evaluate the cause of their liver disease. Results: Seventy-seven consecutive patients were recruited over an eleven month period. Of these, 23 (30%) had increased transaminases because of nevirapine (NVP) and/or isoniazid (INH) hepatotoxicity. Although 14 (61%) patients with drug-induced liver disease presented with jaundice, all recovered with drug discontinuation. Hepatitis B surface antigen was positive in 11 (15%) patients while anti-hepatitis C antibody was reactive in only 2 (3%). Probable granulomatous hepatitis due to tuberculosis was diagnosed in 7 (9%) patients and all responded to anti-TB therapy. Other diagnoses included alcoholic liver disease, AIDS cholangiopathy, hepatocellular carcinoma, schistosomiasis, haemangioma and hepatic adenoma. Twelve (16%) patients died during follow-up of which 7 (9%) died because of liver disease. Conclusion: Drug history, liver enzyme studies, ultrasound, and hepatitis B and C investigations identified the probable etiology in 60 (78%) of 77 patients with HIV infection presenting with symptoms and/or signs of liver disease.enLiver diseasesHIV infected individualsHIV treatment clinicUgandaArticle