Tuberculosis and human immunodeﬁciency virus co-infections and their predictors at a hospital-based HIV/AIDS clinic in Uganda

Nakanjako, D.Mayanja-Kizza, H.Ouma, J.Wanyenze, R.Mwesigire, D.Namale, A.Ssempiira, J.Senkusu, J.Colebunders, R.Kamya, M. R.2022-01-082022-01-082010Nakanjako, D., Mayanja-Kizza, H., Ouma, J., Wanyenze, R., Mwesigire, D., Namale, A., ... & Kamya, M. R. (2010). Tuberculosis and human immunodeficiency virus co-infections and their predictors at a hospital-based HIV/AIDS clinic inUganda. The International journal of tuberculosis and lung disease, 14(12), 1621-1628.https://www.ingentaconnect.com/content/iuatld/ijtld/2010/00000014/00000012/art00021https://nru.uncst.go.ug/xmlui/handle/123456789/1172To evaluate the burden of TB-HIV (tuberculosis-human immunodeficiency virus) co-infections and their predictors in an urban hospital-based HIV programme. DESIGN: Prospective observational study. METHODS: Clinicians screened all patients with HIV/ AIDS (acquired immune-deficiency syndrome) for previous and current TB treatment at enrolment and through- out follow-up. RESULTS: Of 10 924 patients enrolled between August 2005 and February 2009, co-prevalent TB was 157/10 924 (1.4%), which included 88/157 (56%) with TB con- firmed at enrolment and 65/157 (41%) with TB diagnoses established during follow-up in whom symptoms were present at enrolment. Male sex (adjusted odds ratio [aOR] 2.3, 95%CI 1.6–3.2) and body mass index (BMI) ⩽20 kg/m2 (aOR 3.8, 95%CI 2.5–5.4) were associated with co-prevalent TB. Overall, 749/10 767 (7%) were diagnosed with incident TB at a higher rate among anti- retroviral treatment (ART) patients (8/100 patient years of observation [PYO]) than non-ART patients (5/100 PYO, log rank P < 0.001). Female sex (adjusted hazard ratio [aHR] 1.4, 95%CI 1.2–1.7) and baseline BMI ⩽ 20 (aHR 1.9, 95%CI 1.6–2.2) predicted incident TB. CONCLUSION: Routine TB screening in the HIV/AIDS care programme identified a significant number of TB- HIV co-infections among patients with and without ART, and is therefore a potential strategy to improve HIV treatment outcomes in resource-limited settings.enHIV/AIDSTB-HIV co-infectionsTuberculosisARTAfricaTuberculosis and human immunodeﬁciency virus co-infections and their predictors at a hospital-based HIV/AIDS clinic in UgandaArticle