O’Mara, Peter B.Wilde, PatrickBenedetti, Tania M.Andrones, CorinaCheong, SoshanGooding, JustinTilley, Richard D.Schuhmann, Wolfgang2022-12-112022-12-112019O’Mara, P. B., Wilde, P., Benedetti, T. M., Andronescu, C., Cheong, S., Gooding, J. J., ... & Schuhmann, W. (2019). Cascade reactions in nanozymes: Spatially separated active sites inside Ag-Core–Porous-Cu-shell nanoparticles for multistep carbon dioxide reduction to higher organic molecules. Journal of the American Chemical Society, 141(36), 14093-14097. DOI: 10.1021/jacs.9b0731010.1021/jacs.9b07310https://nru.uncst.go.ug/handle/123456789/6203Enzymes can perform complex multistep cascade reactions by linking multiple distinct catalytic sites via substrate channeling. We mimic this feature in a generalized approach with an electrocatalytic nanoparticle for the carbon dioxide reduction reaction comprising a Ag core surrounded by a porous Cu shell, providing different active sites in nanoconfined volumes. The architecture of the nanozyme provides the basis for a cascade reaction, which promotes C−C coupling reactions. The first step occurs on the Ag core, and the subsequent steps on the porous copper shell, where a sufficiently high CO concentration due to the nanoconfinement facilitates C−C bond formation. The architecture yields the formation of n-propanol and propionaldehyde at potentials as low as −0.6 V vs RHE.enCascade ReactionsNanozymesAg-Core−Porous-Cu-Shell NanoparticlesCarbon DioxideOrganic MoleculesArticle