Matthews, Lynn T.Kaida, AngelaKanters, StevenByakwagamd, HelenMocello, A. RainMuzoora, ConradKembabazi, AnnetHaberer, Jessica E.Martin, Jeffrey N.Bangsberg, David R.Hunt, Peter W.2022-01-312022-01-312013Matthews, L. T., Kaida, A., Kanters, S., Byakwaga, H., Mocello, A. R., Muzoora, C., ... & Hunt, P. W. (2013). HIV-infected women on antiretroviral treatment in Uganda have increased mortality during pregnant and postpartum periods. AIDS (London, England), 27(0 1), S105. DOI:10.1097/QAD.000000000000004010.1097/QAD.0000000000000040https://nru.uncst.go.ug/xmlui/handle/123456789/1669To assess the impact of pregnancy on mortality among HIV-infected Ugandan women initiating ART. Prospective cohort study. HIV-infected women initiating ART in the Uganda AIDS Rural Treatment Outcomes study were assessed quarterly for self-reported pregnancy. The association between pregnancy and postpartum (‘pregnancy-related’) follow-up periods and mortality was assessed with Cox proportional hazards models adjusted for age, CD4 cell count, plasma HIV-1 RNA levels, and ART duration. Results: Three hundred and fifty-four women with median age 33 years (IQR: 27–37) and CD4 142 cells/ml (IQR: 82–213) were followed for a median of 4.0 years (IQR: 2.5–4.8) after ART initiation, with 3 and 7% loss-to-follow-up at years 1 and 5. One hundred and nine women experienced pregnancy. Five deaths occurred during pregnancy-related follow-up and 16 during nonpregnancy-related follow-up, for crude mortality rates during the first year after ART initiation of 12.57/100 PYs and 3.53/100 PYs (rate ratio 3.56, 95% CI: 0.97–11.07). In adjusted models, the impact of pregnancy related follow-up on mortality was highest at ART initiation (aHR: 21.48, 95% CI: 3.73–123.51), decreasing to 13.44 (95% CI 3.28–55.11) after 4 months, 8.28 (95% CI 2.38–28.88) after 8 months, 5.18 (95% CI: 1.36–19.71) after 1 year, and 1.25 (95% CI: 0.10–15.58) after 2 years on ART. Four of five maternal deaths occurred postpartum.enAfricaAntiretroviral therapyHIVImmune reconstitutionMaternal healthMaternal mortalityMortalityPostpartumPregnancyWomenArticle