Zandam, Suleiman U.Nazifi, Abdullahi B.Odoma, SaidiZezi, Abdulkadir U.Danjuma, Nuhu M.2023-07-032023-07-032020Zandam, S. U., Nazifi, A. B., Odoma, S., Zezi, A. U., & Danjuma, N. M. (2020). Anti-nociceptive and anti-inflammatory activities of methanol root extract of Andropogon gayanus Kunth (Poaceae) in rodents. African Journal of Pharmacology and Therapeutics, 9(1).https://nru.uncst.go.ug/handle/123456789/9037Andropogon gayanus is widely used in traditional medicine for various ailments such as postpartum pain, bronchitis and oedema. Objective: This study evaluated the anti-nociceptive and anti-inflammatory activities of methanol root extract of A. gayanus in experimental rodents. Methods: Phytochemical screening tests and acute toxicity studies were carried out. Analgesic activity using acetic acid-induced writhing response and hot plate test in mice, formalin-induced pain and carrageenan-induced paw oedema in rats were evaluated at doses of 250, 500 and 1000 mg/kg of the extract. Results: Oral median lethal dose was >5000 mg/kg in both mice and rats. The extract significantly (p<0.01) decreased the number of writhing movements at all tested doses. It also significantly (p<0.05) increased the mean reaction times. A significant (p<0.05) decrease in mean pain scores was also observed in both phases of the formalin test at 1000 mg/kg. The extract at 1000 mg/kg significantly (p<0.05) reduced the oedema at the 1st hour, while at the 5th hour, all doses tested significantly reduced the oedema. Conclusion: The methanol root extract of Andropogon gayanus possesses antinociceptive and anti-inflammatory activitiesAndropogon gayanus is widely used in traditional medicine for various ailments such as postpartum pain, bronchitis and oedema. Objective: This study evaluated the anti-nociceptive and anti-inflammatory activities of methanol root extract of A. gayanus in experimental rodents. Methods: Phytochemical screening tests and acute toxicity studies were carried out. Analgesic activity using acetic acid-induced writhing response and hot plate test in mice, formalin-induced pain and carrageenan-induced paw oedema in rats were evaluated at doses of 250, 500 and 1000 mg/kg of the extract. Results: Oral median lethal dose was >5000 mg/kg in both mice and rats. The extract significantly (p<0.01) decreased the number of writhing movements at all tested doses. It also significantly (p<0.05) increased the mean reaction times. A significant (p<0.05) decrease in mean pain scores was also observed in both phases of the formalin test at 1000 mg/kg. The extract at 1000 mg/kg significantly (p<0.05) reduced the oedema at the 1st hour, while at the 5th hour, all doses tested significantly reduced the oedema. Conclusion: The methanol root extract of Andropogon gayanus possesses antinociceptive and anti-inflammatory activities. Keywords:enAndropogon gayanusAnalgesicAnti-inflammatoryPainArticle