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dc.contributor.authorMartins, Karen A.
dc.contributor.authorAyebare, Rodgers R.
dc.contributor.authorBhadelia, Nahid
dc.contributor.authorKiweewa, Francis
dc.contributor.authorWaitt, Peter
dc.contributor.authorMimbe, Derrick
dc.contributor.authorOkello, Stephen
dc.contributor.authorNaluyima, Prossy
dc.contributor.authorBrett-Major, David M.
dc.contributor.authorLawler, James V.
dc.contributor.authorMillard, Monica
dc.contributor.authorWalwema, Richard
dc.contributor.authorCardile, Anthony P.
dc.contributor.authorRitchie, Chi
dc.contributor.authorKwiecien, Antonia
dc.contributor.authorBadu, Helen
dc.contributor.authorEspinosa, Benjamin J.
dc.contributor.authorBeckett, Charmagne
dc.contributor.authorBavari, Sina
dc.contributor.authorZaman, Saima
dc.contributor.authorChristopher, George
dc.contributor.authorClark, Danielle V.
dc.contributor.authorLamorde, Mohammed
dc.contributor.authorKibuuka, Hannah
dc.date.accessioned2022-12-08T18:40:23Z
dc.date.available2022-12-08T18:40:23Z
dc.date.issued2020
dc.identifier.citationMartins, K. A., Ayebare, R. R., Bhadelia, N., Kiweewa, F., Waitt, P., Mimbe, D., ... & Kibuuka, H. (2020). Pre-positioned Outbreak Research: The Joint Medical Emerging Diseases Intervention Clinical Capability Experience in Uganda. Health security, 18(2), 114-124. DOI: 10.1089/hs.2019.0112en_US
dc.identifier.other10.1089/hs.2019.0112
dc.identifier.urihttps://nru.uncst.go.ug/handle/123456789/6067
dc.description.abstractThe West Africa Ebola virus disease outbreak of 2014-2016 demonstrated that responses to viral hemorrhagic fever epidemics must go beyond emergency stopgap measures and should incorporate high-quality medical care and clinical research. Optimal patient management is essential to improving outcomes, and it must be implemented regardless of geographical location or patient socioeconomic status. Coupling clinical research with improved care has a significant added benefit: Improved data quality and management can guide the development of more effective supportive care algorithms and can support regulatory approvals of investigational medical countermeasures (MCMs), which can alter the cycle of emergency response to reemerging pathogens. However, executing clinical research during outbreaks of high-consequence pathogens is complicated and comes with ethical and research regulatory challenges. Aggressive care and excellent quality control must be balanced by the requirements of an appropriate infection prevention and control posture for healthcare workers and by overcoming the resource limitations inherent in many outbreak settings. The Joint Mobile Emerging Disease Intervention Clinical Capability was established in 2015 to develop a high-quality clinical trial capability in Uganda to support rigorous evaluation of MCMs targeting high-consequence pathogens like Ebola virus. This capability assembles clinicians, laboratorians, clinical researchers, logisticians, and regulatory professionals trained in infection prevention and control and in good clinical and good clinical laboratory practices. The resulting team is prepared to provide high-quality medical care and clinical research during high-consequence outbreaks.en_US
dc.language.isoenen_US
dc.publisherHealth securityen_US
dc.subjectMedical countermeasuresen_US
dc.subjectInfectious diseasesen_US
dc.subjectViral hemorrhagic feversen_US
dc.subjectOutbreak responseen_US
dc.subjectUgandaen_US
dc.titlePre-positioned Outbreak Research: The Joint Medical Emerging Diseases Intervention Clinical Capability Experience in Ugandaen_US
dc.typeArticleen_US


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