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dc.contributor.authorChurch, Jessica D.
dc.contributor.authorHuang, Wei
dc.contributor.authorMwatha, Anthony
dc.contributor.authorMusoke, Philippa
dc.contributor.authorJackson, J. Brooks
dc.contributor.authorBagenda, Danstan
dc.contributor.authorOmer, Saad B.
dc.contributor.authorDonnell, Deborah
dc.contributor.authorNakabiito, Clemensia
dc.contributor.authorEure, Chineta
dc.contributor.authorGuay, Laura A.
dc.contributor.authorTaylor, Allan
dc.contributor.authorBakaki, Paul M.
dc.contributor.authorMatovu, Flavia
dc.contributor.authorMcConnell, Michelle
dc.contributor.authorFowler, Mary Glenn
dc.contributor.authorEshleman, Susan H.
dc.date.accessioned2021-12-15T09:23:16Z
dc.date.available2021-12-15T09:23:16Z
dc.date.issued2010
dc.identifier.citationD Church, Jessica, Wei Huang, Anthony Mwatha, Philippa Musoke, J. Brooks Jackson, Danstan Bagenda, Saad B Omer et al. "Analysis of HIV tropism in Ugandan infants." Current HIV research 8, no. 7 (2010): 498-503. https://doi.org/10.2174/157016210793499187en_US
dc.identifier.urihttps://doi.org/10.2174/157016210793499187
dc.identifier.urihttps://nru.uncst.go.ug/xmlui/handle/123456789/556
dc.description.abstractHIV-infected infants may have CXCR4-using (X4-tropic) HIV, CCR5-using (R5-tropic) HIV, or a mixture of R5-tropic and X4-tropic HIV (dual/mixed, DM HIV). The level of infectivity for R5 virus (R5-RLU) varies among HIV-infected infants. HIV tropism and R5-RLU were measured in samples from HIV-infected Ugandan infants using a commercial assay. DM HIV was detected in 7/72 (9.7%) infants at the time of HIV diagnosis (birth or 6–8 weeks of age, 4/15 (26.7%) with subtype D, 3/57 (5.3 %) with other subtypes, P=0.013). A transition from R5-tropic to DM HIV was observed in only two (6.7%) of 30 infants over 6–12 months. Six (85.7%) of seven infants with DM HIV died, compared to 21/67 (31.3%) infants with R5-tropic HIV (p=0.09). Higher R5- RLU at 6–8 weeks was not associated with decreased survival. Infants with in utero infection had a higher median R5-RLU than infants who were HIV-uninfected at birth (p=0.025).en_US
dc.language.isoenen_US
dc.publisherCurrent HIV researchen_US
dc.subjectCCR5en_US
dc.subjectCXCR4en_US
dc.subjectHIV-1en_US
dc.subjectInfanten_US
dc.subjectSurvivalen_US
dc.subjectTransmissionen_US
dc.subjectTropismen_US
dc.titleAnalysis of HIV tropism in Ugandan infantsen_US
dc.typeArticleen_US


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