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    Naphthoquinones from the Roots of Aloe Secundiflora

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    Article (211.7Kb)
    Date
    2012
    Author
    Indul, Martha
    Cheloti, Michael
    Wasuna, Antonina
    Wekesa, Ingrid
    Wanjohi, John M.
    Byamukama, Robert
    Heydenrich, Matthias
    Makayoto, Moses
    Yenesew, Abiy
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    Abstract
    Two new naphthoquinones, 5-hydroxy-3,6-dimethoxy-2-methylnaphthalene-1,4-dione and 5,8-dihydroxy- 3-methoxy-2-methylnaphthalene-1,4-dione, were isolated from the roots of Aloe secundiflora together with the known compounds chrysophanol, helminthosporin, isoxanthorin, ancistroquinone C, aloesaponarins I and II, aloesaponols I and II, laccaic acid D methyl ester and asphodelin. The structures were elucidated based on spectroscopic evidence. This appears to be the first report on the occurrence of naphthoquinones in the genus Aloe. Aloesaponarin I and 5-hydroxy-3,6-dimethoxy-2-methylnaphthalene- 1,4-dione showed anti-bacterial activity against Mycobacterium tuberculosis with MIC values of 21– 23 mg/mL in the Microplate Alamar Blue Assay (MABA) and Low Oxygen Recovery Assay (LORA); 5- hydroxy-3,6-dimethoxy-2-methylnaphthalene-1,4-dione also showed cytotoxicity against the Vero cell line (IC50 = 10.2 mg/mL).
    URI
    http://dx.doi.org/10.1016/j.phytol.2012.04.014
    https://nru.uncst.go.ug/xmlui/handle/123456789/478
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    • Agricultural and Veterinary Sciences [1451]

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