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dc.contributor.authorRedd, Andrew D.
dc.contributor.authorDabitao, Djeneba
dc.contributor.authorBream, Jay H.
dc.contributor.authorCharvat, Blake
dc.contributor.authorLaeyendecker, Oliver
dc.contributor.authorKiwanuka, Noah
dc.contributor.authorLutalo, Tom
dc.contributor.authorKigozi, Godfrey
dc.contributor.authorTobian, Aaron A. R.
dc.contributor.authorGamiel, Jordyn
dc.contributor.authorNeal, Jessica D.
dc.contributor.authorOliver, Amy E.
dc.contributor.authorMargolick, Joseph B.
dc.contributor.authorReynolds, Steven J.
dc.contributor.authorSewankambo, Nelson K.
dc.contributor.authorWawer, Maria J.
dc.contributor.authorSerwadda, David
dc.contributor.authorGray, Ronald H.
dc.contributor.authorQuinn, Thomas C.
dc.date.accessioned2022-03-11T05:49:43Z
dc.date.available2022-03-11T05:49:43Z
dc.date.issued2009
dc.identifier.citationRedd, A. D., Dabitao, D., Bream, J. H., Charvat, B., Laeyendecker, O., Kiwanuka, N., ... & Quinn, T. C. (2009). Microbial translocation, the innate cytokine response, and HIV-1 disease progression in Africa. Proceedings of the National Academy of Sciences, 106(16), 6718-6723.en_US
dc.identifier.urihttps://www.pnas.org/content/106/16/6718.short
dc.identifier.urihttps://nru.uncst.go.ug/xmlui/handle/123456789/2670
dc.description.abstractReports from the United States have demonstrated that elevated markers of microbial translocation from the gut may be found in chronic and advanced HIV-1 infection and are associated with an increase in immune activation. However, this phenomenon’s role in HIV-1 disease in Africa is unknown. This study examined the longitudinal relationship between microbial translocation and circulating inflammatory cytokine responses in a cohort of people with varying rates of HIV-1 disease progression in Rakai, Uganda. Multiple markers for microbial translocation (lipopolysaccharide, endotoxin antibody, and sCD14) did not change significantly during HIV-1 disease progression. Moreover, circulating immunoreactive cytokine levels either decreased or remained virtually unchanged throughout disease progression. These data suggest that microbial translocation and its subsequent inflammatory immune response do not have a causal relationship with HIV-1 disease progression in Africa.en_US
dc.language.isoenen_US
dc.publisherNational Academy of Sciencesen_US
dc.subjectHIVen_US
dc.subjectmicrobial translocationen_US
dc.titleMicrobial translocation, the innate cytokine response, and HIV-1 disease progression in Africaen_US
dc.typeArticleen_US


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