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dc.contributor.authorBaker, Allison R.
dc.contributor.authorZalwango, Sarah
dc.contributor.authorMalone, LaShaunda L.
dc.contributor.authorIgo Jr, Robert P.
dc.contributor.authorQiu, Feiyou
dc.contributor.authorNsereko, Mary
dc.contributor.authorAdams, Mark D.
dc.contributor.authorSupelak, Pamela
dc.date.accessioned2021-12-10T11:16:14Z
dc.date.available2021-12-10T11:16:14Z
dc.date.issued2011
dc.identifier.citationBaker, A. R., Zalwango, S., Malone, L. L., Igo Jr, R. P., Qiu, F., Nsereko, M., ... & Stein, C. M. (2011). Genetic susceptibility to tuberculosis associated with cathepsin Z haplotype in a Ugandan household contact study. Human immunology, 72(5), 426-430. doi:10.1016/j.humimm.2011.02.016.en_US
dc.identifier.other10.1016/j.humimm.2011.02.016.
dc.identifier.urihttps://nru.uncst.go.ug/xmlui/handle/123456789/245
dc.description.abstractTuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), causes 9 million new cases worldwide and 2 million deaths annually. Genetic linkage and association analyses have suggested several chromosomal regions and candidate genes involved in TB susceptibility. This study examines the association of TB disease susceptibility with a selection of biologically relevant genes on regions on chromosomes 7 (IL6 and CARD11) and 20 (CTSZ and MC3R) and fine mapping of the chromosome 7p22–p21 region identified through our genome scan. We analyzed 565 individuals from Kampala, Uganda, who were previously included in our genome-wide linkage scan. Association analyses were conducted for 1,417 single-nucleotide polymorphisms (SNP) that passed quality control. None of the candidate gene or fine mapping SNPs was significantly associated with TB susceptibility (p 0.10). When we restricted the analysis to HIV-negative individuals, 2 SNPs on chromosome 7 were significantly associated with TB susceptibility (p 0.05). Haplotype analyses identified a significant risk haplotype in cathepsin X (CTSZ; p 0.0281, odds ratio 1.5493, 95% confidence interval [1.039, 2.320]).en_US
dc.language.isoenen_US
dc.publisherElsevier Inc.en_US
dc.subjectInfectious diseaseen_US
dc.subjectFamily studyen_US
dc.subjectTB geneticsen_US
dc.subjectFine mapen_US
dc.subjectImmunogeneticsen_US
dc.titleGenetic susceptibility to tuberculosis associated with cathepsin Z haplotype in a Ugandan household contact studyen_US
dc.typeArticleen_US


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