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Adherence To Antiretroviral Therapy In Children Attending Mulago Hospital, Kampala

Barungi, Nicolette Nabukeera; Kalyesubula, Israel; Kekitiinwa, Addy; Tusiime, Jayne Byakika; Musoke, Philippa (Annals of tropical paediatrics, 2007)

Non-adherence reduces the effectiveness of antiretroviral therapy in children attending the paediatric HIV/AIDS clinic at Mulago Hospital, Kampala.To determine the levels of adherence to HAART and identify factors associated ...

Associations of Chemokine Receptor Polymorphisms With HIV-1 Mother-to-Child Transmission in Sub-Saharan Africa: Possible Modulation of Genetic Effects by Antiretrovirals

Singh, Kumud K.; Hughes, Michael D.; Chen, Jie; Phiri, Kelesitse; Rousseau, Christine; Kuhn, Louise; Coutsoudis, Anna; Jackson, J. Brooks; Guay, Laura A.; Musoke, Philippa; Mmiro, Francis; Semba, Richard D.; Spector, Stephen A. (Journal of acquired immune deficiency syndromes, 2008)

HIV-1 mother-to-child transmission (MTCT) remains an important route of infection in sub-Saharan Africa.Genetic variants in CCR5 promoter, CCR2, CX3CR1, and Stromal cell-derived factor-1 (SDF-1) genes were determined in ...

Characterization of Nevirapine Resistance Mutations in Women With Subtype A Vs. D HIV-1 6–8 Weeks After Single-Dose Nevirapine (HIVNET 012)

Eshleman, Susan H.; Guay, Laura A.; Mwatha, Anthony; Brown, Elizabeth R.; Cunningham, Shawn P.; Musoke, Philippa; Mmiro, Francis; Jackson, J. Brooks (JAIDS Journal of Acquired Immune Deficiency Syndromes, 2004)

To compare the number and type of nevirapine (NVP) resistance mutations detected in Ugandan women with subtype A vs.D HIV-1 infection after single-dose NVP prophylaxis.In the HIVNET 012 trial, a higher rate of NVP resistance ...

Adherence to antiretroviral therapy in children attending Mulago Hospital, Kampala

Nabukeera-Barungi, Nicolette; Kalyesubula, Israel; Kekitiinwa, Addy; Byakika-Tusiime, Jayne; Musoke, Philippa (Annals of tropical Paediatrics, 2007)

Background: Non-adherence reduces the effectiveness of antiretroviral therapy in children attending the paediatric HIV/AIDS clinic at Mulago Hospital, Kampala. Aim: To determine the levels of adherence to HAART and ...

Bacteraemia In Severely Malnourished Children In An HIV-Endemic Setting

Iriso, Esther Babirekere; Musoke, Philippa; Kekitiinwa, Adeodata (Annals of tropical paediatrics, 2006)

HIV infection predisposes children with malnutrition to recurrent bacterial infections and a high risk of bacteraemia.A cross-sectional descriptive study to determine the prevalence, causative organisms, antibiotic sensitivity ...

Vertical Transmission Of X4-Tropic And Dual-Tropic HIV-1 In Five Ugandan Mother–Infant Pairs

Huang, Wei; Eshleman, Susan H.; Toma, Jonathan; Stawiski, Eric; Whitcomb, Jeannette M.; Jackson, J. Brooks; Guay, Laura; Musoke, Philippa; Parkin, Neil; Petropoulos, Christos J. (AIDS (London, England), 2009)

We previously reported the existence of CXCR4-using HIV-1 in 6–14 week-old Ugandan infants. Whether these viruses were transmitted from the mother perinatally or evolved after transmission is not known. In the current ...

Bacteraemia in severely malnourished children in an HIV-endemic setting

Babirekere-Iriso, Esther; Musoke, Philippa; Kekitiinwa, Adeodata (Annals of tropical paediatrics, 2006)

Background: HIV infection predisposes children with malnutrition to recurrent bacterial infections and a high risk of bacteraemia. Methods: A cross-sectional descriptive study to determine the prevalence, causative ...

Coreceptor Tropism in Human Immunodeficiency Virus Type 1 Subtype D: High Prevalence of CXCR4 Tropism and Heterogeneous Composition of Viral Populations

Huang, Wei; Eshleman, Susan H.; Toma, Jonathan; Fransen, Signe; Stawiski, Eric; Paxinos, Ellen E.; Whitcomb, Jeannette M.; Young, Alicia M.; Donnell, Deborah; Mmiro, Francis; Musoke, Philippa; Guay, Laura A.; Jackson, J. Brooks; Parkin, Neil T.; Petropoulos, Christos J. (Journal of virology, 2007)

In human immunodeficiency virus type 1 (HIV-1) subtype B, CXCR4 coreceptor use ranges from ∼20% in early infection to ∼50% in advanced disease. Coreceptor use by non-subtype B HIV is less well characterized. We studied ...

Longitudinal Antiretroviral Adherence in HIV+ Ugandan Parents and Their Children Initiating HAART in the MTCT-Plus Family Treatment Model: Role of Depression in Declining Adherence Over Time

Tusiime, Jayne Byakika; Crane, Johanna; Oyugi, Jessica H.; Ragland, Kathleen; Kawuma, Annet; Musoke, Philippa; Bangsberg, David R. (AIDS and Behavior, 2009)

We conducted a study to assess the effect of family-based treatment on adherence amongst HIV-infected parents and their HIV-infected children attending the Mother-To-Child-Transmission Plus program in Kampala, Uganda. ...

Comparison of Laboratory Methods for Analysis of Non-nucleoside Reverse Transcriptase Inhibitor Resistance in Ugandan Infants

Church, Jessica D.; Huang, Wei; Parkin, Neil; Marlowe, Natalia; Guay, Laura A.; Omer, Saad B.; Musoke, Philippa; Jackson, J. Brooks; Eshleman, Susan H. (2009)

Detailed comparisons of HIV drug resistance assays are needed to identify the most useful assays for research studies, and to facilitate comparison of results from studies that use different methods. We analyzed nonnucleoside ...