Analysis of Attained Height and Diabetes Among 554,122 Adults Across 25 Low- and Middle Income Countries

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Date
2020Author
Teufel, Felix
Geldsetzer, Pascal
Manne-Goehler, Jennifer
Karlsson, Omar
Koncz, Viola
Deckert, Andreas
Theilmann, Michaela
Marcus, Maja-Emilia
Ebert, Cara
Seiglie, Jacqueline A.
Agoudavi, Kokou
Andall-Brereton, Glennis
Gathecha, Gladwell
Gurung, Mongal S.
Guwatudde, David
Houehanou, Corine
Hwalla, Nahla
Kagaruki, Gibson B.
Karki, Khem B.
Labadarios, Demetre
Martins, Joao S.
Msaidie, Mohamed
Norov, Bolormaa
Sibai, Abla M.
Sturua, Lela
Tsabedze, Lindiwe
Wesseh, Chea S.
Davies, Justine
Atun, Rifat
Vollmer, Sebastian
Subramanian, S.V.
Barnighausen, Till
Jaacks, Lindsay M.
Neve, Jan-Walter De
Metadata
Show full item recordAbstract
The prevalence of type 2 diabetes is rising rapidly in low-income and middle-income
countries (LMICs), but the factors driving this rapid increase are notwell understood.
Adult height, in particular shorter height, has been suggested to contribute to the
pathophysiology and epidemiology of diabetes and may inform how adverse
environmental conditions in early life affect diabetes risk. We therefore systematically analyzed the association of adult height and diabetes across LMICs, where
such conditions are prominent.
RESEARCH DESIGN AND METHODS
We pooled individual-level data from nationally representative surveys in LMICs
that included anthropometric measurements and diabetes biomarkers. We calculated odds ratios (ORs) for the relationship between attained adult height and
diabetes using multilevel mixed-effects logistic regression models. We estimated
ORs for the pooled sample,major world regions, and individual countries, in addition
to stratifying all analyses by sex. We examined heterogeneity by individual-level
characteristics.
RESULTS
Our sample included 554,122 individuals across 25 population-based surveys.
Average height was 161.7 cm (95% CI 161.2–162.3), and the crude prevalence of
diabetes was 7.5% (95% CI 6.9–8.2). We found no relationship between adult height
and diabetes across LMICs globally or in most world regions. When stratifying our
sample by country and sex, we found an inverse association between adult height
and diabetes in 5% of analyses (2 out of 50). Results were robust to alternative model
specifications.
CONCLUSIONS
Adult height is not associated with diabetes across LMICs. Environmental factors in
early life reflected in attained adult height likely differ from those predisposing
individuals for diabetes.
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- Medical and Health Sciences [3670]