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    Long-term dominance of Mycobacterium tuberculosis Uganda family in peri-urban Kampala-Uganda is not associated with cavitary disease

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    Date
    2013
    Author
    Wampande, Eddie M.
    Mupere, Ezekiel
    Debanne, SaraM
    Asiimwe, Benon B.
    Nsereko, Mary
    Mayanja, Harriet
    Eisenach, Kathleen
    Kaplan, Gilla
    Boom, Henry W.
    Gagneux, Sebastien
    Joloba, Moses L.
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    Abstract
    Previous studies have shown that Mycobacterium tuberculosis (MTB) Uganda family, a sub-lineage of the MTB Lineage 4, is the main cause of tuberculosis (TB) in Uganda. Using a well characterized patient population, this study sought to determine whether there are clinical and patient characteristics associated with the success of the MTB Uganda family in Kampala. A total of 1,746 MTB clinical isolates collected from1992-2009 in a household contact study were genotyped. Genotyping was performed using Single Nucleotide Polymorphic (SNP) markers specific for the MTB Uganda family, other Lineage 4 strains, and Lineage 3, respectively. Out of 1,746 isolates, 1,213 were from patients with detailed clinical data. These data were used to seek associations between MTB lineage/sub-lineage and patient phenotypes.
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    https://nru.uncst.go.ug/xmlui/handle/123456789/1646
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    • Medical and Health Sciences [3670]

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