Long-term dominance of Mycobacterium tuberculosis Uganda family in peri-urban Kampala-Uganda is not associated with cavitary disease

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Date
2013Author
Wampande, Eddie M.
Mupere, Ezekiel
Debanne, SaraM
Asiimwe, Benon B.
Nsereko, Mary
Mayanja, Harriet
Eisenach, Kathleen
Kaplan, Gilla
Boom, Henry W.
Gagneux, Sebastien
Joloba, Moses L.
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Previous studies have shown that Mycobacterium tuberculosis (MTB) Uganda family, a sub-lineage of the MTB Lineage 4, is the main cause of tuberculosis (TB) in Uganda. Using a well characterized patient population, this study sought to determine whether there are clinical and patient characteristics associated with the success of the MTB Uganda family in Kampala.
A total of 1,746 MTB clinical isolates collected from1992-2009 in a household contact study were genotyped. Genotyping was performed using Single Nucleotide Polymorphic (SNP) markers specific for the MTB Uganda family, other Lineage 4 strains, and Lineage 3, respectively. Out of 1,746 isolates, 1,213 were from patients with detailed clinical data. These data were used to seek associations between MTB lineage/sub-lineage and patient phenotypes.
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- Medical and Health Sciences [3670]