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dc.contributor.authorTornesello, Maria Lina
dc.contributor.authorBiryahwaho, Benon
dc.contributor.authorDowning, Robert
dc.contributor.authorHatzakis, Angelo
dc.contributor.authorAlessi, Elvio
dc.contributor.authorCusini, Marco
dc.contributor.authorRuocco, Vincenzo
dc.contributor.authorMbidde, Edward Katongole
dc.contributor.authorLoquercio, Giovanna
dc.contributor.authorBuonaguro, Luigi
dc.contributor.authorBuonaguro, Franco M.
dc.date.accessioned2022-01-24T20:27:25Z
dc.date.available2022-01-24T20:27:25Z
dc.date.issued2010
dc.identifier.citationTornesello, M. L., Biryahwaho, B., Downing, R., Hatzakis, A., Alessi, E., Cusini, M., ... & Buonaguro, F. M. (2010). Human herpesvirus type 8 variants circulating in Europe, Africa and North America in classic, endemic and epidemic Kaposi's sarcoma lesions during pre-AIDS and AIDS era. Virology, 398(2), 280-289.https://doi.org/10.1016/j.virol.2009.12.005en_US
dc.identifier.issn0042-6822
dc.identifier.urihttps://nru.uncst.go.ug/xmlui/handle/123456789/1529
dc.description.abstractHuman herpesvirus-8 (HHV-8) variants have been found heterogeneously distributed among human populations living in diverse geographic regions, but their differential pathogenicity in Kaposi's sarcoma development remains controversial. In the present study, HHV-8 variant distribution has been analyzed in classic, iatrogenic, endemic as well as epidemic Kaposi's sarcoma (KS) during pre-AIDS and AIDS period (1971–2008) in countries with different KS incidence rate. DNA samples from cutaneous KS lesions of 68 patients living in Africa (n = 23, Cameroon, Kenya and Uganda), Europe (n = 34, Greece and Italy) and North America (n = 11) have been subjected to PCR amplification of HHV-8 ORF 26, T0.7, K1 and K14.1/15, followed by direct nucleotide sequencing and phylogenetic analysis. Among the 23 African samples, the majority of HHV-8 ORF 26 variants clustered with the subtype R (n = 12) and B (n = 5). Conversely, the viral sequences obtained from 45 European and North European tumors belonged mainly to subtype A/C (n = 36). In general, HHV-8 and K1 variant clustering paralleled that of ORF 26 and T0.7. Genotyping of the K14.1/15 loci revealed a large predominance of P subtype in all tumors. In conclusion, comparison of the HHV-8 sequences from classic or endemic versus AIDS-associated KS showed a strong linkage of the HHV-8 variants with specific populations, which has not changed during AIDS epidemic.en_US
dc.language.isoenen_US
dc.publisherVirologyen_US
dc.subjectKaposi's sarcoma; Human herpes virus type 8; (HHV-8)HHV-8 ORF 26; HHV-8 ORF K1en_US
dc.titleHuman Herpesvirus Type 8 Variants Circulating In Europe, Africa And North America In Classic, Endemic And Epidemic Kaposi's Sarcoma Lesions During Pre-AIDS and AIDS Eraen_US
dc.typeArticleen_US


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