Vaginal Cytomegalovirus Shedding Before and After Initiation of Antiretroviral Therapy in Rakai, Uganda

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Date
2015Author
Gianella, Sara
Redd, Andrew D.
Grabowski, Mary K.
Tobian, Aaron A. R.
Serwadda, David
Newell, Kevin
Patel, Eshan U.
Kalibbala, Sarah
Ssebbowa, Paschal
Gray, Ronald H.
Quinn, Thomas C.
Reynolds, Steven J.
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Vaginal shedding of cytomegalovirus (CMV) DNA was determined longitudinally among 96 women coinfected with human immunodeficiency virus (HIV), herpes simplex virus 2, and CMV starting antiretroviral therapy (ART) during a placebo-controlled trial of HSV-2 suppression with acyclovir in Rakai, Uganda. Vaginal CMV was detected in 75 of 96 women (78.0%) and 379 of 1080 individual visits (35.1%). ART status, higher HIV RNAviral load before ART initiation, and younger age were significantly associated with increased frequency of CMV shedding (P < .01). Compared to pre- ART, CMV shedding peaked from month 2 to month 4 after ART initiation, suggesting possible immune reconstitution inflammatory syndrome. Further studies need to determine the clinical significance of asymptomatic CMV shedding.
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- Medical and Health Sciences [3670]