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dc.contributor.authorWalimbwa, Stephen I.
dc.contributor.authorLamorde, Mohammed
dc.contributor.authorWaitt, Catriona
dc.contributor.authorKaboggoza, Julian
dc.contributor.authorElse, Laura
dc.contributor.authorByakika-Kibwika, Pauline
dc.contributor.authorAmara, Alieu
dc.contributor.authorGini, Joshua
dc.contributor.authorWinterberg, Markus
dc.contributor.authorChiong, Justin
dc.contributor.authorTarning, Joel
dc.contributor.authorKhoob, Saye H.
dc.date.accessioned2022-01-12T09:58:50Z
dc.date.available2022-01-12T09:58:50Z
dc.date.issued2018
dc.identifier.citationWalimbwa SI, Lamorde M, Waitt C, Kaboggoza J, Else L, Byakika-Kibwika P, Amara A, Gini J, Winterberg M, Chiong J, Tarning J, Khoo SH. 2019. Drug interactions between dolutegravir and artemether-lumefantrine or artesunate-amodiaquine. Antimicrob Agents Chemother 63:e01310-18. https://doi.org/10 .1128/AAC.01310-18.en_US
dc.identifier.urihttps://doi.org/10 .1128/AAC.01310-18.
dc.identifier.urihttps://nru.uncst.go.ug/xmlui/handle/123456789/1211
dc.description.abstractAcross sub-Saharan Africa, patients with HIV on antiretrovirals often getmalaria and need cotreatment with artemisinin-containing therapies. We undertook two pharmacokinetic studies in healthy volunteers, using standard adult doses of artemetherlumefantrine or artesunate-amodiaquine given with 50mg once daily dolutegravir (DTG) to investigate the drug-drug interaction between artemether-lumefantrine or artesunateamodiaquine and dolutegravir. The dolutegravir/artemether-lumefantrine interaction was evaluated in a two-way crossover study and measured artemether, dihydroartemisinin, lumefantrine, and desbutyl-lumefantrine over 264 h. The dolutegravir/artesunate-amodiaquine interaction was investigated using a parallel study design due to long half-life of the amodiaquine metabolite, desethylamodiaquine and measured artesunate, amodiaquine, and desethylamodiaquine over 624 h.en_US
dc.language.isoenen_US
dc.publisherAntimicrobial agents and chemotherapyen_US
dc.subjectDolutegraviren_US
dc.subjectMalariaen_US
dc.subjectArtemetheren_US
dc.subjectArtesunateen_US
dc.subjectLumefantrineen_US
dc.subjectAmodiaquineen_US
dc.subjectDrug-drug interactionsen_US
dc.titleDrug Interactions between Dolutegravir and Artemether- Lumefantrine or Artesunate-Amodiaquineen_US
dc.typeArticleen_US


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