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    Assessment of parasite clearance following treatment of severe malaria with intravenous artesunate in Ugandan children enrolled in a randomized controlled clinical trial

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    Article (934.4Kb)
    Date
    2018
    Author
    Byakika‑Kibwika, Pauline
    Nyakato, Patience
    Lamorde, Mohammed
    Kiragga, Agnes N.
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    Abstract
    Worldwide, malaria ranks as one of the most important causes of morbidity and mortality with 216 million cases and 445,000 deaths in 2016 alone, 90% of cases and deaths occur in Africa and 80% in sub-Saharan Africa Uganda is one of the heavy malaria burden countries where Plasmodium falciparum, which causes the most severe form of disease is the most prevalent [1]. Malaria is transmitted by the female Anopheles mosquito which injects sporozoites into the human host. Sporozoites undergo pre-erythrocytic and erythrocytic stages of multiplication causing erythrocyte rupture with release of merozoites and pro-inflammatory cytokines into circulation, which are responsible for the symptoms. Patients seek medical attention when they begin to experience symptoms of malaria.
    URI
    https://doi.org/10.1186/s12936-018-2552-6
    https://nru.uncst.go.ug/xmlui/handle/123456789/1204
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