A Systematic Review Protocol to Establish Plasmodium Falciparum Genetic Diversity, Multiplicity of Infection, Genotyping Approaches, and Methods of Reporting It in Africa.
Nankabirwa, Joaniter Immaculate
Lubwama Nsobya, Samuel
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P. falciparum is the most important Plasmodium species that causes high malaria morbidity and mortality. The distribution of diverse and multiple P. falciparum infections is a major setback to the control and eventual elimination of malaria globally. Little efforts have been made to systematically establish P. falciparum genetic diversity and multiplicity of infection (MOI) in African settings. Additionally, the choice of an effective P. falciparum genotyping approach for a specific endemic setting remains a challenge. The review aims to establish P. falciparum genetic diversity MOI, genotyping approaches, and methods of reporting it in Africa. This will aid the evaluation of the impact of malaria control interventions and development of new control strategies.
- Medical and Health Sciences