Browsing by Author "Dumontet, Vincent"

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    Cycloartane triterpenes from the leaves of Neoboutonia macrocalyx L.
    (Elsevier, 2014) Namukobe, Jane; Kiremire, Bernard T.; Byamukama, Robert; Kasenene, John M.; Dumontet, Vincent; Guéritte, Françoise; Krief, Sabrina; Florent, Isabelle; Kabasa, John D
    Neoboutonia macrocalyx is used by people in south western Uganda around Kibale National Park in the treatment of malaria. Phytochemical investigation on the leaves of this plant led to the isolation of nine cycloartane triterpenes (1–9) and one phenanthrene; 7-methoxy-2,8 dimethyl-9, 10-dihydrophenantherene-3,6 diol (10) along with three known compounds which included 22-de-Oacetyl- 26-deoxyneoboutomellerone (11), mellerin B (12) and 6-hydroxystigmast-4-en-3-one (13). The chemical structures of the compounds were established mainly through a combination of spectroscopic techniques. The isolated compounds were evaluated for antiplasmodial activity against the chloroquine-resistant FcB1/Colombia strain of Plasmodium falciparum and for cytotoxicity against the KB (nasopharyngeal epidermoid carcinoma) and MRC-5 (human diploid embryonic lung) cells. Seven out of 13 compounds exhibited good antiplasmodial activity with IC50 of 65 lg/ml with two compounds exhibiting low cytotoxicity and five compounds having significant cytotoxicity.
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    Traditional plants used for Medicinal purposes by local communities around the Northern sector of Kibale National Park, Uganda
    (Elsevier, 2011) Namukobe, Jane; Kasenene, John.M.; Kiremire, Bernard T.; Byamukama, Robert; Kamatenesi-Mugisha, Maud; Krief, Sabrina; Dumontet, Vincent; Kabasa, John D.
    Ethnopharmacological relevance: The study was done to establish medicinal plants used in the treatmentof various diseases by the people in the Northern sector of Kibale National Park in western Uganda. Itwas also aimed at establishing the plant parts used and the mode of preparation of remedies. Theseplants create a basis for phytochemical evaluation which can lead to the discovery of biologically activecompounds that can be used as starting materials in the development of new drugs targetingselected diseases such as malaria. Materials and methods: The required information was obtained using open interviews, semi-structured questionnaires, focus group discussions and transect walks. Results: Different medicinal plants (131 species) distributed over 55 families were observed to be used by the local communities around the Northern sector of Kibale National Park. The plants as reported in this paper are used to treat 43 physical illnesses/diseases. The most used parts of the plants are the leaves. Water is the main medium used for the preparation of the remedies which are mostly administered orally. Conclusion: The people in the study area have a rich heritage of traditional plants that are used in the health care system to treat diseases. These medicinal plants have contributed significantly to several disease therapies. The most common diseases treated are malaria and cough, which are mostly treated by Vernonia amygdalina Del. and Albizia coriaria Welw. respectively. The main sources of medicinal plants include bush land, home gardens, grasslands, and the forest.