Browsing by Author "Agostinelli, Claudio"

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    Immunohistochemical and other prognostic factors in B cell non Hodgkin lymphoma patients, Kampala, Uganda
    (BMC Clinical Pathology, 2009) Tumwine, Lynnette K.; Agostinelli, Claudio; Campidelli, Cristina; Othieno, Emmanuel; Wabinga, Henry; Righi, Simona; Falini, Brunangelo; Piccaluga, Pier Paolo; Byarugaba, Wilson
    Non Hodgkin lymphomas are the most common lymphomas in Uganda. Recent studies from developed countries have shown differences in survival for the different immunophenotypes. Such studies are lacking in Africa where diagnosis is largely dependent on morphology alone. We report immunohistochemical and other prognostic factors in B cell non Hodgkin lymphoma patients in Kampala, Uganda. Methods: Non Hodgkin lymphoma tissue blocks from the archives of the Department of Pathology, Makerere University College of Health Sciences, Kampala, Uganda, from 1991-2000, were sub typed using haematoxylin and eosin, Giemsa as well as immunohistochemistry. Using tissue micro array, 119 biopsies were subjected to: CD3, CD5, CD10, CD20, CD23, CD30, CD38, CD79a, CD138, Bcl-6, Bcl-2, IRTA-1, MUM1/IRF4, Bcl-1/cyclin D1, TdT, ALKc, and Ki-67/Mib1. Case notes were retrieved for: disease stage, chemotherapy courses received and retrospective follow up was done for survival.